Proadrenomedullin N-terminal 20 peptide suppresses nicotinic receptor-mediated adrenal catecholamine release by blocking voltage-dependent Ca2+ channels in anesthetized dogs
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منابع مشابه
Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors.
Proadrenomedullin N-terminal 20 peptide (PAMP-[1-20]; ARLDVASEFRKKWNKWALSR-amide) is a potent hypotensive and catecholamine release-inhibitory peptide released from chromaffin cells. We studied the mechanism of PAMP action and how its function is linked to structure. We tested human PAMP-[1-20] on catecholamine secretion in PC12 pheochromocytoma cells and found it to be a potent, dose-dependent...
متن کاملInhibitory effects of proadrenomedullin N-terminal 20 peptide on antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs.
The effects of proadrenomedullin N-terminal 20 peptide (PAMP) on changes in renal function and norepinephrine (NE) overflow induced by renal nerve stimulation (RNS) were examined in anesthetized dogs. The intrarenal arterial infusion of PAMP (10, 50, 100 ng/kg/min) did not influence basal levels of systemic and renal hemodynamics, or urine formation. RNS at a low frequency (0.5-2.0 Hz) caused s...
متن کاملAREGU Apr. 45/4
Masada, Kimiya, Takahiro Nagayama, Akio Hosokawa, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Tomohiko Kimura, and Susumu Satoh. Effects of adrenomedullin and PAMP on adrenal catecholamine release in dogs. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1118–R1124, 1999.—We examined the effects of proadrenomedullin-derived peptides on the release of adrenal catecholamine...
متن کاملRole of K+ channels in adrenal catecholamine secretion in anesthetized dogs.
We examined the role of K+ channels in the secretion of adrenal catecholamine (CA) in response to splanchnic nerve stimulation (SNS), acetylcholine (ACh), 1,1-dimethyl-4-phenyl-piperazinium (DMPP), and muscarine in anesthetized dogs. K+ channel blockers and the cholinergic agonists were infused and injected, respectively, into the adrenal gland. The voltage-dependent K+ channel (KA type) blocke...
متن کاملPhytoestrogen cimicifugoside-mediated inhibition of catecholamine secretion by blocking nicotinic acetylcholine receptor in bovine adrenal chromaffin cells.
We investigated the effect of the phytoestrogen cimicifugoside, one of the pharmacologically active ingredients of the medicinal plant Cimicifuga racemosa (black cohosh) that has been used to treat many kinds of neuronal and menopausal symptoms, such as arthritis, menopausal depression, and nerve pain. Cimicifugoside inhibited calcium increase induced by 1,1-dimethyl-4-phenylpiperazinium iodide...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)40614-8